Regenerative Medicine and Muse Cells: The Science Behind Our Technologies

Our innovative programs are built on the achievements of regenerative medicine, including Muse cells (Multi-lineage differentiating stress enduring cells) — endogenous pluripotent stem cells discovered by the research group of Professor Mari Dezawa (Tohoku University, Japan).

Medical editor: Vitalia Kurach · Reviewed by a doctor · Updated: 09.08.2026

What are Muse cells

Muse cells are natural, non-cancerous pluripotent stem cells found in the connective tissue of nearly every organ, in bone marrow and in peripheral blood. From a single cell, they can give rise to cells of all three germ layers — potentially any tissue in the body.

The key difference from other pluripotent cells is safety: Muse cells have low telomerase activity and, in experiments, do not form teratomas (tumors) — confirmed, in particular, by transplantation into immunodeficient animals with follow-up of up to six months.

How they work in the body

• when administered systemically, they selectively accumulate in damaged tissue (via the S1P–S1PR2 receptor axis);
• at the site of damage, they spontaneously differentiate into cells compatible with that tissue: in the liver — into hepatocytes; in muscle — into dystrophin-expressing cells; in the nervous system — into neural-lineage cells;
• they have immunosuppressive and immunomodulatory effects — significant for autoimmune diseases;
• they are resistant to stress and DNA damage thanks to active repair systems;
• they are obtained from normal tissue (bone marrow, skin, adipose tissue) without genetic manipulation.

Why we apply regenerative technologies responsibly

The term "stem cells" has attracted everything from hype to skepticism. The truth lies in between: regeneration is a natural biological process that requires the right conditions in the body. That's why applying these techniques is always preceded by a thorough work-up involving at least three specialists, including oncology screening. There are clear contraindications: malignant processes, transplanted organs, epilepsy. We do not take on everyone — roughly 25–30% of applicants are declined if treatment cannot be made safe.

Questions & Answers

Sources

• Kuroda Y., Dezawa M. et al. Unique multipotent cells in adult human mesenchymal cell populations. PNAS, 2010.
• Dezawa M. Muse Cells Provide the Pluripotency of Mesenchymal Stem Cells. Cell Transplantation, 2016.
• Research materials from the Tohoku University (Japan) group studying Muse cells.

Author: PERFECT IMPERIAL Private Medical Institute editorial team.

Medical editor: Vitalia Kurach — dermatovenereologist, sexopathologist, andrologist, dermatosurgeon; specialist in intimate contouring and regenerative medicine; Medical Director of the Institute.

Published: 09.08.2026 · Updated: 09.08.2026

This material is for informational purposes only and does not replace a doctor's consultation. Contraindications exist — a specialist consultation is required. Expected results are described based on the clinic's experience; individual results depend on the patient's baseline condition and adherence to recommendations.